Design of Experiments (DOE) using JMP (1.0 days)

DOE using JMP (1.0 days): This course focuses on how to establish a systematic approach to pharmaceutical development using design of experiments (DOE). All concepts are taught within the product quality system framework.

Design of Experiments (DOE) using JMP:

• identify critical quality attributes (CQAs) that will be used as responses in your designs
• utilize risk management tools to identify and prioritize potential critical process parameters
• identify critical process parameters and develop a functional relationship between those process
  parameters and your critical-to-quality attributes (CQAs) using both screening and response surface
  designs
• be able to design and analyze screening designs including a factorial, fractional factorial, and D-optimal
  design
• understand the need for adding center points to a design
• be able to design and analyze response surface designs including central composite designs (CCDs),
  Box-Behnken designs, and I-optimal designs
• be able to design and analyze definitive screening designs
• present results of DOE studies

Outline:

1. Introduction to Design of Experiments (DOE)
   • steps to DOE
   • defining critical-to-quality attributes (CQAs)
   • identifying and prioritizing potential process parameters
2. Screening Designs – Identifying Critical Process Parameters
   • factorial designs
   • fractional factorial designs
   • D-optimal designs
3. Response Surface Designs – Develop Functional Relationships and Establish Design Space
   • Central Composite Designs (CCDs)
   • Box-Behnken designs (Self Study)
   • I-optimal designs

Other Design of Experiments Classes and Training